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Stochastic kinetics of viral capsid assembly based on detailed protein structures.
Martin Hemberg, Sophia N. Yaliraki and Mauricio Barahona
"We present a generic computational framework for the simulation of viral capsid assembly which is quantitative and specific. Starting from PDB files containing atomic coordinates, the algorithm builds a coarse grained description of protien oligomers based on graph rigidity. [...] We also show how in this model the quasistationary kinetics of assembly can be described as a Markovian cascading process in which only a few intermediates and a small proportion of pathways are present... [Read More...] |
