FIRST/FRODA code was modified to implement
Hybrid-36 (
http://cci.lbl.gov/hybrid_36/) PDB format. Now PDB files can handle up to 87,440,031 ATOM with unique serial numbers and up to 24,36,111 residue sequence numbers per chain. The difference between "traditional" and hybrid-36 PDB files becomes evident only if there are more than 99,999 atoms in the file.
The processing of a structure with more than 99,999 atoms with FRODA will be available only on stand alone FIRST/FRODA, the on-line version of FRODA will stay with processing of structures with less than 99,999 atoms. On-line FIRST will be able to analyze structures with more than 99,999 atoms.
It is possible to upload zipped PDB stucture to web FIRST/FRODA.
I added encode_hybrid_36.py Python script to util directory and attached it to this post. This script converts PDB files to hybrid-36 format.
Please test out large PDB structures and let me know if you notice any problems with it.